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JAC Advance Access published online on April 25, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg230
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

Efficacy of caspofungin combined with amphotericin B against azole-resistant Candida albicans

Mohammad A. Hossain 1, Guadalupe H. Reyes 1, Lisa A. Long 1, Pranab K. Mukherjee 1, Mahmoud A. Ghannoum 2

1 Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5028
2 Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5028; University Hospitals of Cleveland, Cleveland, OH 44106, USA

Received 25 September 2002 ; revised 1 December 2002 ; accepted 26 February 2003

Abstract

The activity of caspofungin (CFG) combined with amphotericin B (AMB) against azole-resistant Candida albicans was evaluated in vitro (chequerboard) and in vivo (murine). CFG+AMB resulted in positive interactive effects in vitro (fractional inhibitory concentration index 0.75). Compared with untreated controls, CFG+AMB prolonged mouse survival (P = 0.006) and compared with AMB alone, CFG+AMB prolonged mouse survival (P = 0.36); however, the latter difference was not signficant. CFG+AMB treatment significantly reduced kidney cfu compared with untreated controls and CFG-treated groups (P <= 0.05 for both comparisons). In addition, this combination reduced brain cfu significantly compared with untreated controls and AMB-treated mice (P = 0.005 and 0.05, respectively).

Keywords: disseminated candidiasis, antifungal, therapy
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