JAC Advance Access published online on April 25, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg229
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 CSIRO Livestock Industries, Private Bag 24, Geelong, Victoria
3220, Australia
Received 27 November 2002
; revised 23 January 2003
; accepted 25 February 2003
Objective: We have conducted a series
of experiments to show that the bacteriocin piscicolin 126 (P126)
retains antilisterial activity after injection into a mouse. Methods: Groups of mice were challenged intravenously
with Listeria monocytogenes and treated with purified
P126 at varying times before and after challenge to determine whether administration
of this peptide reduced numbers of colonizing L. monocytogenes and
the symptoms of listeriosis. Results: The bacteriocin P126 retained antilisterial
activity after injection into the mouse. During the early time-points
of listerial infection, the purified P126 was found to significantly
reduce the listerial load in the liver and spleen and, further,
that this reduction translated to reduced clinical signs of disease. Conclusions: This is the first report of a Class
IIA bacteriocin displaying in vivo antimicrobial activity.
Such a result provides preliminary evidence that this class of molecules
may be useful in controlling systemic bacterial infections.
Keywords: bacteriocin, in vivo activity,
piscicolin 126
The bacteriocin piscicolin 126 retains antilisterial
activity in vivo
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