Skip Navigation



JAC Advance Access published online on April 14, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg201
© 2003 by The British Society for Antimicrobial Chemotherapy
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
51/5/1213    most recent
dkg201v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Decousser, J.-W.
Right arrow Articles by Allouch, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Decousser, J.-W.
Right arrow Articles by Allouch, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2003 The British Society for Antimicrobial Chemotherapy

Original article

Frequency of isolation and antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections: a French prospective national survey

J.-W. Decousser 1, P. Pina 1, F. Picot 1, C. Delalande 1, B. Pangon 1, P. Courvalin 2, P. Allouch 1*

1 Centre Hospitalier A. Mignot, Versailles
2 Institut Pasteur, Paris

* Corresponding author. E-mail: PALLOUCH{at}ch-versailles.fr.

Received 22 November 2002 ; revised 21 December 2002 ; accepted 9 February 2003

Abstract

All bloodstream strains, total 1463, isolated during a 1 month period in 105 hospitals representing all geographical areas in France were collected to study their antimicrobial susceptibility. The three major species were Escherichia coli, Staphylococcus aureus and coagulase-negative staphylococci. Among the 242 S. aureus, 87 were resistant to methicillin and among those 99% were resistant to ciprofloxacin, 11.5% to gentamicin, 1% to quinupristin/dalfopristin and 8% were heterogeneously resistant to vancomycin. Study of the methicillin-resistant S. aureus indicated that 12 clones had disseminated in French hospitals, six being heterogeneously resistant to vancomycin. Among the Streptococcus pneumoniae, 43% showed decreased susceptibility to the penicillins and 42% to erythromycin. One isolate was highly resistant to fluoroquinolones. Gentamicin, cefotaxime, ciprofloxacin and gatifloxacin resistance was rare in Enterobacteriaceae with 95% of strains susceptible. The incidence of extended-spectrum {beta}-lactamases was quite low. Moreover more than 25% of Pseudomonas aeruginosa strains were resistant to ciprofloxacin and gentamicin. The magnitude of antibiotic resistance in bloodstream isolates, in particular Gram-positive bacteria, emphasizes the importance of hospital control measures, rational prescribing policies and new vaccine strategies.

Keywords: bloodstream infection, antimicrobial susceptibility, VRSA, Streptococcus pneumoniae, France
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Appl. Environ. Microbiol.Home page
P. L. Tran, A. A. Hammond, T. Mosley, J. Cortez, T. Gray, J. A. Colmer-Hamood, M. Shashtri, J. E. Spallholz, A. N. Hamood, and T. W. Reid
Organoselenium Coating on Cellulose Inhibits the Formation of Biofilms by Pseudomonas aeruginosa and Staphylococcus aureus
Appl. Envir. Microbiol., June 1, 2009; 75(11): 3586 - 3592.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. Galas, J.-W. Decousser, N. Breton, T. Godard, P. Y. Allouch, P. Pina, and and the College de Bacteriologie Virologie Hygiene
Nationwide Study of the Prevalence, Characteristics, and Molecular Epidemiology of Extended-Spectrum-{beta}-Lactamase-Producing Enterobacteriaceae in France
Antimicrob. Agents Chemother., February 1, 2008; 52(2): 786 - 789.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
B. E. E. Cleven, M. Palka-Santini, J. Gielen, S. Meembor, M. Kronke, and O. Krut
Identification and characterization of bacterial pathogens causing bloodstream infections by DNA microarray.
J. Clin. Microbiol., July 1, 2006; 44(7): 2389 - 2397.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J.-W. Decousser, I. Methlouthi, P. Pina, A. Collignon, P. Allouch, and on behalf of the ColBVH Study Group
New Real-Time PCR Assay Using Locked Nucleic Acid Probes To Assess Prevalence of ParC Mutations in Fluoroquinolone-Susceptible Streptococcus pneumoniae Isolates from France.
Antimicrob. Agents Chemother., April 1, 2006; 50(4): 1594 - 1598.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
K. Poole
Aminoglycoside Resistance in Pseudomonas aeruginosa
Antimicrob. Agents Chemother., February 1, 2005; 49(2): 479 - 487.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
N. van der Mee-Marquet, A.-S. Domelier, N. Girard, R. Quentin, and the Bloodstream Infection Study Group of the Relai
Epidemiology and Typing of Staphylococcus aureus Strains Isolated from Bloodstream Infections
J. Clin. Microbiol., December 1, 2004; 42(12): 5650 - 5657.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.