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JAC Advance Access published online on March 13, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg190
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing

Brendan W. Mason 1*, Anthony J. Howard 2, John T. Magee 1

1 Public Health Laboratory Service, Communicable Disease Surveillance Centre (Wales), Abton House, Wedal Road, Cardiff CF14 3QX
2 Department of Medical Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff CF14 4XW, UK

* Corresponding author. E-mail: Brendan.mason{at}phls.wales.nhs.uk.

Received 17 October 2002 ; revised 4 December 2002 ; accepted 3 February 2003

Abstract

The level of resistance to fusidic acid among community methicillin-susceptible Staphylococcus aureus (MSSA) isolates in the UK and prescriptions for fusidic acid have both doubled over the past 6 years. It is hypothesized that selective pressure arising from topical use of fusidic acid in the community accounts for this increase. A significant correlation was found between prescribing of fusidic acid and resistance at the practice level (Spearman's rho = 0.46, 95% confidence interval 0.11-0.71, P = 0.01). Further controlled studies are required to determine whether this association is causal.

Keywords: fusidic acid resistance, Staphylococcus aureus, fusidic acid prescribing
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