JAC Advance Access published online on March 13, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg171
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Medical Microbiology,
Medical School, Teviot Place, University of Edinburgh, Edinburgh
EH8 9AG, UK; Institute of Medical Microbiology,
Semmelweis University, Budapest
* Corresponding author. E-mail: S.G.B.Amyes{at}ed.ac.uk.
Received 23 October 2002
; revised 4 December 2002
; accepted 18 January 2003
Objective: Hungary has reported one
of the highest incidences of penicillin resistance in Streptococcus
pneumoniae in Europe since the 1970s and is still cited accordingly.
However, since the end of the 1990s the resistance of pneumococci
in Hungary has not been investigated. In this study we assessed
the current situation, particularly to establish whether the incidence
of resistance is increasing and if this could be related to the
spread of specific strain types. Methods: Isolates of S. pneumoniae (n = 304) were collected by five diagnostic
laboratories in Hungary in 2000-2002. Their identity was
confirmed and their susceptibilities to 16 antibiotics were determined
by the agar dilution method according to NCCLS guidelines. Representative strains
were serotyped (n = 112). Results and conclusions: We found significantly
lower resistance rates for penicillin compared with the data previously
reported from Hungary, but the intermediate resistance was high,
at 37%. Macrolide resistance was a bigger problem (
Keywords: Streptococcus pneumoniae, Hungary,
macrolide resistance, penicillin resistance, serotyping
Antibiotic susceptibility and serotypes of Streptococcus
pneumoniae isolates from Hungary
2 Institute of Medical Microbiology,
Semmelweis University, Budapest
3 Department
of Clinical Microbiology, Faculty of Medicine, University of Szeged,
Szeged
4 Aladár
Petz County Teaching Hospital, Gy
r, Hungary
5 Medical Microbiology,
Medical School, Teviot Place, University of Edinburgh, Edinburgh
EH8 9AG, UK
40% for erythromycin), although
there was full susceptibility to telithromycin. The strains with
the highest MICs were isolated from carriers and young children.
The fluoroquinolones were very effective, especially moxifloxacin
and gatifloxacin. There was full susceptibility to vancomycin and
linezolid. We found inconsistencies with previous reports in the
survey of the resistance and identification of S. pneumoniae in
the country. The serotype distribution of the isolates showed a
much greater diversity than had previously been reported; however,
there was correlation between serotype and resistance.
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