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JAC Advance Access published online on March 13, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg169
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Original article

An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii

Isabelle Plante 1, Daniela Centrón 2, Paul H. Roy 1*

1 Centre de Recherche en Infectiologie, Centre Hospitalier de l'Université Laval, 2705 Boul. Laurier; Département de Biochimie et de Microbiologie, Faculté des Sciences et de Génie, Université Laval, Ste-Foy, Québec, Canada
2 University of Buenos Aires, Faculty of Medicine, Department of Microbiology, Paraguay 2155, Piso 12, 1121 Capital Federal, Argentina

* Corresponding author. E-mail: paul.roy{at}crchul.ulaval.ca.

Received 21 October 2002 ; revised 13 December 2002 ; accepted 21 January 2003

Abstract

We have mapped the variable region of the two class 1 integrons found in the multiresistant strain Providencia stuartii 1723. Integron 1 contains a new arrangement of gene cassettes, aacA4-aadB-aadA1, conferring resistance to all aminoglycosides used for clinical treatment. Integron 2 contains a variant of the gene cassette ere(A), coding for an erythromycin esterase, whose nucleotide sequence shares 93.7% DNA identity with ere(A) from Escherichia coli BM2195 plasmid pIP1100.

Keywords: resistance, aminoglycosides, sequencing
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