JAC Advance Access published online on March 13, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg167
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Department of Microbiology, The Chinese University of Hong
Kong, The Prince of Wales Hospital, Shatin,
New Territories, Hong Kong SAR, China
* Corresponding author. E-mail: meilunling{at}cuhk.edu.hk.
Received 6 October 2002
; revised 4 December 2002
; accepted 21 January 2003
This study was initiated throughout Hong Kong, to reveal
the characteristics of community-acquired infections. All specimens
collected by general practitioners from infected patients were followed
prospectively, and those that were culture-positive were analysed.
Four thousand seven hundred and forty-one specimens were collected
from 3977 patients by 89 doctors from July 2000 to October 2001.
The most common specimens were throat swabs (33%), urine
(26%) and sputa (16%). The average culture-positive
rate was 28%. The most common organisms were Escherichia
coli (18%),
Keywords: community-acquired infections, antimicrobial
susceptibilities
What have we learnt from community-acquired infections
in
Hong Kong?
-haemolytic
streptococci (15%) and Staphylococcus aureus (12%). Fluoroquinolone
resistance was relatively high (up to 35%) in organisms
commonly causing urinary tract infection (E. coli, Proteus and Morganella). Although
none of the pneumococci was resistant to penicillin 1 mg/L, the
proportion with intermediate resistance (0.1-1 mg/L) was alarming
(81%). There were three strains of methicillin-resistant S. aureus. A decrease in ampicillin
resistance but a high prevalence of macrolide resistance were noted
in Haemophilus influenzae. All Neisseria
gonorrhoeae isolates were resistant to penicillin, up to 79% to
the fluoroquinolones, 15% to spectinomycin, but all were
susceptible to ceftriaxone. Respiratory pathogens (Streptococcus
pneumoniae, -haemolytic streptococci
and H. influenzae) were relatively
susceptible to the newer fluoroquinolones (0-2%,
0.5-6% and 2% resistant, respectively) or
third-generation cephalosporins (0-2% resistant).
The distribution of organisms and their antibiotic resistance varied
over time. Thus frequent surveillance is needed to provide information
on the drugs of choice for different infections.
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