JAC Advance Access published online on March 13, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg161
© 2003 by The British Society for Antimicrobial Chemotherapy
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Brief report
1 Université des
Sciences et Techniques de Masuku (USTM), Franceville; Centre International de Recherches Médicales
de Franceville (CIRMF), B.P. 769 Franceville, Gabon
* Corresponding author. E-mail: cnkoule{at}yahoo.fr.
Received 9 July 2002
; revised 26 September 2002
; accepted 21 January 2003
Objectives: To assess the activity
of a new organometallic chloroquine analogue, ferroquine, against
numerous Plasmodium falciparum isolates from Gabon. Methods: The in vitro susceptibility
of 116 P. falciparum isolates to chloroquine and
ferroquine was assessed using the isotopic microtest. All isolates
were from outpatients in the Franceville and Bakoumba medical centres
in the province of Haut-Ogooué, south-east Gabon. Results: The in vitro resistance
to chloroquine was 51.8% in Franceville and 96.7% in
Bakoumba. The IC50 geometric mean (95% CI) of
ferroquine against isolates in Franceville was 16.0
(14.4-17.8) nM, with individual values ranging from 1.0
to 47.0 nM; in Bakoumba it was 27.9 (23.4-33.2) nM,
with individual values ranging from 1.0 to 62.0 nM. Compared with
chloroquine, ferroquine was 5.3 times more active on isolates susceptible
to chloroquine, and 13.3 times more active on isolates resistant
to chloroquine. A weak positive correlation was observed between
responses of these two drugs, but too low to demonstrate cross-resistance. Conclusions: Ferroquine may be useful as an
alternative drug for treating chloroquine-resistant malaria.
Keywords: chloroquine, ferrocene, malaria
In vitro susceptibility to a new
antimalarial organometallic analogue, ferroquine, of Plasmodium
falciparum isolates from the Haut-Ogooué region of
Gabon
2 Centre International de Recherches Médicales
de Franceville (CIRMF), B.P. 769 Franceville, Gabon
3 Université des Sciences
et Techniques
de Lille (USL), Villeneuve d'Ascq, France
4 Université des
Sciences et Techniques de Masuku (USTM), Franceville, Gabon
5 Centre International de Recherches Médicales
de Franceville (CIRMF), B.P. 769 Franceville, Gabon; Institut de Recherche pour le Développement
UR010, Faculté de Pharmacie, Université Paris
5, Paris, France
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