JAC Advance Access published online on March 13, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg156
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Institut für
Medizinische Mikrobiologie und Immunologie, Pharmazeutische Mikrobiologie,
Meckenheimer Allee 168, University of Bonn, D-53115 Bonn
* Corresponding author. E-mail: IngoStock{at}web.de.
Received 2 April 2002
; revised 8 August 2002
; accepted 13 January 2003
The natural susceptibility to 71 antibiotics of 104 Serratia strains of Serratia ficaria (n = 15), Serratia fonticola (n = 18), Serratia odorifera (n = 16), Serratia plymuthica (n = 32) and Serratia rubidaea
(n = 23) was examined. MICs were determined
using a microdilution procedure in IsoSensitest broth for all the
strains and in cation-adjusted Mueller-Hinton broth for
some strains. With few exceptions, all species tested
were uniformly naturally resistant to penicillin G, oxacillin, cefazolin,
cefuroxime, all tested macrolides, lincosamides, streptogramins,
glycopeptides, fusidic acid and rifampicin, and naturally sensitive
to several aminoglycosides, piperacillin, piperacillin/tazobactam,
carbapenems, some cephalosporins, fluoroquinolones and folate-pathway
inhibitors. Major species-related differences in natural susceptibility
affecting clinical assessment criteria were seen with tetracyclines,
some aminoglycosides, aminopenicillins, ticarcillin, cefaclor, loracarbef,
cefoxitin, pipemidic acid, chloramphenicol, nitrofurantoin and fosfomycin.
Differences in susceptibility dependent on the medium were seen
with macrolides, tetracycline, fosfomycin and some
Natural antimicrobial susceptibilities of strains
of ‘unusual'
Serratia species: S. ficaria, S.
fonticola, S. odorifera, S. plymuthica and S. rubidaea
2 Institut für Pharmazeutische
Biologie und Mikrobiologie, Bundesstrasse 45, University of Hamburg,
D-20146 Hamburg, Germany
-lactams.
The natural antibiotic susceptibility patterns suggest novel species-specific
mechanisms of antibiotic resistance. Uncharacterized species-specific
aminoglycoside-modifying enzymes and multidrug efflux systems affecting
tetracyclines, quinolones and chloramphenicol are probably responsible
for some of the phenotypes observed. The natural amoxicillin sensitivity
of several strains of some species combined with natural resistance
to some narrow-spectrum cephalosporins indicate the expression of
naturally occurring -lactamases with
unique substrate profiles. -Lactamases
of representative strains of each species were characterized phenotypically
and genotypically. It was shown that all species expressed naturally
occurring AmpC -lactamases and, with
respect to S. fonticola, also a species-specific
class A -lactamase. Inducibility of
these enzymes was shown in all species with the exception of S.
rubidaea and four of five strains of S. plymuthica.
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