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JAC Advance Access published online on February 11, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg144
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Original article

The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum)

Stephen R. Davis 1*, Rosemary Perrie 1, Rafael Apitz-Castro 2

1 Mycology Unit, Women's and Children's Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
2 Instituto Venezolano de Investigaciones Científicas (IVIC), Lab. Trombosis Experimental Centro de Biofísisca y Bioquímica, Caracas, Ap. 21827, 1020-A, Venezuela

* Corresponding author. E-mail: sdavis{at}esc.net.au.

Received 15 June 2002 ; revised 29 October 2002 ; accepted 10 January 2003

Abstract

The in vitro susceptibility of 20 medical isolates of Scedosporium prolificans to ajoene, allitridium and raw garlic extract derived from cloves of garlic (Allium sativum) was tested using the NCCLS reference method (with minor modifications) for broth microdilution. The results demonstrate that both garlic derivatives and raw garlic extract appear to have in vitro activity against S. prolificans.

Keywords: antifungal, ajoene, allitridium, garlic
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