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JAC Advance Access published online on February 11, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg140
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Original article

Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital

Hee-Jeong Yun 1, Sang Won Lee 1, Gyu Man Yoon 1, Su Yeon Kim 2, Sooyoung Choi 2, Yeong Seon Lee 3, Eung-Chil Choi 1, Sunghoon Kim 1*

1 National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Gu, Seoul 151-742
2 Imagene Co., Ltd, Biotechnology Incubating Center, Seoul National University, Seoul 151-742
3 Laboratory of Antimicrobial Resistant Pathogens, Department of Microbiology, National Institute of Health, Seoul 122-701, Korea

* Corresponding author. E-mail: sungkim{at}snu.ac.kr.

Received 16 September 2002 ; revised 4 December 2002 ; accepted 5 January 2003

Abstract

Mupirocin has been used against Gram-positive pathogenic bacteria, and is a specific inhibitor of bacterial isoleucyl-tRNA synthetase. In this work, we have determined the prevalence of mupirocin resistance among staphylococci isolated from a Korean hospital, and have investigated the characteristics of the resistance. In Staphylococcus aureus, the prevalence of high-level mupirocin resistance was 5% (16 of 319), whereas low-level mupirocin resistance was not detected. In coagulase-negative staphylococci (CoNS) the rates of high- and low-level mupirocin resistance were 16.7% (34 of 204) and 10.3% (21 of 204), respectively. The high-level resistant strains contained the ileS-2 gene, which encodes a novel staphylococcal isoleucyl-tRNA synthetase. In contrast, all of the low-level mupirocin-resistant CoNS contained the mutation V588F, which is located near the conserved motif KMSKS, within the chromosomal staphylococcal isoleucyl-tRNA synthetase gene (ileS). In conclusion, this work describes the recent, but rapid, emergence of two different types of mupirocin-resistant staphylococci in Korea, and the sequence and mutant characterization of the isoleucyl-tRNA synthetase of CoNS.

Keywords: mupirocin, staphylococci, resistance mechanism
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