JAC Advance Access published online on February 11, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg130
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Focus Technologies, 13665
Dulles Technology Drive, Suite 200, Herndon, VA 20171-4603
* Corresponding author. E-mail: jkarlowsky{at}focusanswers.com.
Received 27 August 2002
; revised 3 December 2002
; accepted 20 December 2002
Antibiotic resistance was prevalent in Gram-positive
pathogens collected from 40 sites in 15 European countries
during 2000-2001. Among Staphylococcus aureus,
27.3% of all isolates submitted were resistant to oxacillin
and ranged from 0% of isolates from the Netherlands to 36.9% of
isolates from Portugal. The overall prevalence of vancomycin-resistant Enterococcus faecium was 25.1%, with Italy
submitting the largest percentage of resistant isolates (60.6%).
For Streptococcus pneumoniae, 9.4% of
all isolates collected were resistant to penicillin with variation
by country from 0% in the Netherlands to 20.7% in
Portugal. Multidrug resistance (MDR), defined as concurrent resistance
to three or more antimicrobials of different chemical classes, was
observed in 24.6% of S. aureus, 19.6% of E. faecium and 3.6% of S.
pneumoniae. The directed spectrum agents daptomycin, linezolid
and quinupristin-dalfopristin were active in
vitro against all isolates regardless of their resistance to
other agents. Daptomycin and quinupristin-dalfopristin
(MIC90s 0.5 mg/L) were equally active against oxacillin-resistant S. aureus compared with linezolid (MIC90 2
mg/L). The activities of daptomycin, quinupristin-dalfopristin
and linezolid were not affected by resistance to vancomycin in E. faecium (MIC90s of 4, 2 and 2 mg/L, respectively).
Daptomycin was more active against penicillin-resistant S.
pneumoniae (MIC90 0.25 mg/L) than was quinupristin-dalfopristin
(MIC90 0.5 mg/L) or linezolid (MIC90 2 mg/L). Daptomycin
was highly active against clinically important Gram-positive pathogens,
including those that were multiply resistant to currently available
agents. The results of this study provide a benchmark of the activity
of daptomycin against contemporary European isolates and will serve
as a baseline to monitor future changes in the susceptibility of
these organisms to daptomycin.
Keywords: daptomycin, Gram-positive pathogens, multidrug-resistant
Activity of daptomycin against susceptible and
multidrug-resistant Gram-positive pathogens collected in the SECURE
study (Europe) during 2000-2001
2 Focus Technologies, Franklin, TN
37064, USA
3 Focus Technologies,
Koninginneweg 11, 1217 KP Hilversum, The Netherlands
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