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JAC Advance Access published online on January 28, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg121
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Original article

A multidrug efflux phenotype mutant of Streptococcus pyogenes

H. E. Jones 1, N. P. Brenwald 1, K. A. Owen 1, M. J. Gill 1*

1 Division of Immunity & Infection, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

* Corresponding author. E-mail: m.j.gill{at}bham.ac.uk.

Received 20 September 2001 ; revised 8 February 2002 ; accepted 13 December 2002

Abstract

We describe a mutant of Streptococcus pyogenes NCTC 8198 with a multidrug efflux phenotype. A mutant selected with ethidium bromide showed a four-fold rise in MIC of norfloxacin, a 16-fold rise in MIC of ethidium bromide and an eight-fold rise in MIC of acriflavine when compared with the parent strain. The MICs were unaffected by the efflux pump inhibitors reserpine, rescinnamine and verapamil. The mutant's ethidium bromide MIC was reduced two-fold by norfloxacin. Ethidium bromide accumulation after 10 min was 58% lower in the mutant compared with the parent. This difference was not affected by carbonyl cyanide m-chlorophenylhydrazone.


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