JAC Advance Access published online on January 28, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg105
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Institut für
Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für
Orthopädie und Sportorthopädie
* Corresponding author. E-mail: h.gollwitzer{at}lrz.tu-muenchen.de.
Received 4 September 2002
; revised 16 October 2002
; accepted 26 November 2002
Objectives: Biomaterial-associated
bacterial infections present common and challenging complications
with medical implants. The purpose of this study was to determine
the antibacterial properties of a low molecular weight biodegradable
poly(D,L-lactic acid) coating
with integrated antibiotics gentamicin and teicoplanin. Methods: Coating of Kirschner-wires was carried
out by a solvent casting technique under aseptic conditions with
and without incorporated antibiotics. Release kinetics of gentamicin
and teicoplanin were studied in phosphate-buffered saline. Initial
bacterial adhesion of Staphylococcus epidermidis on
coated and bare implants was determined by radiolabelling and counts of
detached viable organisms. Results: The incorporated antibiotics showed
a continuous release over a period of at least 96 h with an initial
peak of release in the first 6 h. Attachment of non-viable microorganisms,
detected by radiolabelled bacteria, was increased significantly
by the polymer coatings (P < 0.05). In contrast,
the number of viable bacteria was reduced by the pure polymer (P < 0.01) and further by the polymer-antibiotic
combinations (P < 0.05). Conclusions: Poly(D,L-lactic
acid) coating of implants could offer new perspectives in preventing biomaterial-associated
infections. Combinations with other drugs to formulate custom-tailored implant
surfaces are feasible.
Keywords: polylactide, PDLLA, drug release, Staphylococcus,
biomaterial
Antibacterial poly(D,L-lactic
acid) coating of medical implants using a biodegradable drug delivery
technology
2 Institut für
Experimentelle Onkologie und Therapieforschung
3 Klinik und Poliklinik für
Orthopädie und Sportorthopädie
4 Institut für Medizinische
Statistik und Epidemiologie, der Technischen Universität
München, Ismaninger Strasse 22, 81675 Munich, Germany
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