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JAC Advance Access published online on January 14, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg090
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Original article

Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

Dimitrios P. Kontoyiannis 1*, Russell E. Lewis 2, Nir Osherov 3, Nathaniel D. Albert 3, Gregory S. May 3

1 Department of Infectious Diseases, Infection Control & Employee Health, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 402, Houston, TX 77030
2 Department of Infectious Diseases, Infection Control & Employee Health, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 402, Houston, TX 77030; Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, TX
3 Department of Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

* Corresponding author. E-mail: dkontoyi{at}mdanderson.org.

Received 1 July 2002 ; revised 13 September 2002 ; accepted 19 November 2002

Abstract

Work in Saccharomyces cerevisiae and Cryptococcus neoformans suggests that caspofungin could interact with the calcineurin pathway. We examined the in vitro interaction of caspofungin with calcineurin inhibitors (FK506, cyclosporin, FK520 and L685,818) and the TOR inhibitor rapamycin in 13 isolates of Aspergillus species. Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted.

Keywords: caspofungin, calcineurin inhibitors
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