JAC Advance Access published online on January 6, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg080
© 2003 by The British Society for Antimicrobial Chemotherapy
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Brief report
1 Department of Paediatrics
A and Unit of Infectious
Diseases, Schneider Children's Medical Center of Israel,
14 Kaplan Street, Petah Tiqva 49202; Felsenstein Medical Research Centre, Petah Tiqva
* Corresponding author. E-mail: ashai{at}post.tau.ac.il.
Received 19 July 2002
; revised 26 September 2002
; accepted 7 November 2002
Appropriate antibiotic treatment of shigellosis depends
on identifying resistance patterns. By studying Shigella isolates
in central Israel from 1998 to 2000, and comparing with the period 1991-1992,
we identified a significantly increased resistance to tetracycline
(from 23% to 87%, P < 0.00001),
high resistance to trimethoprim-sulfamethoxazole (94%)
and ampicillin (85%) and emerging resistance to quinolones
(0.5-2%). These data mandate local monitoring
of resistance and its consideration in empirical therapy.
Keywords: diarrhoea, shigellosis, antibiotic therapy
Growing antimicrobial resistance of Shigella isolates
2 Unit of Infectious
Diseases, Schneider Children's Medical Center of Israel,
14 Kaplan Street, Petah Tiqva 49202; Sackler Faculty of Medicine, Tel
Aviv University, Tel Aviv
3 Department
of Clinical Microbiology,
Rabin Medical Center, Petah Tiqva, Israel
4 Sackler Faculty of Medicine, Tel
Aviv University, Tel Aviv; Department
of Clinical Microbiology,
Rabin Medical Center, Petah Tiqva, Israel
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