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JAC Advance Access published online on January 6, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg048
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief report

Effect of ciprofloxacin on adhesive properties of non-P mannose-resistant uropathogenic Escherichia coli isolates

Claudia Balagué 1, Luisa Fernández 1, Jorgelina Pérez 1, Roberto Grau 1*

1 Department of Microbiology, Rosario University School of Biochemistry and Pharmacy, and Institute for Molecular and Cellular Biology (IBR-CONICET), Suipacha 531, Rosario 2000, Argentina

* Corresponding author. E-mail: rrgrau{at}infovia.com.ar.

Received 22 March 2002 ; revised 13 August 2002 ; accepted 18 October 2002

Abstract

The influence of sub-MIC of ciprofloxacin on the surface properties of 25 non-P mannose-resistant uropathogenic Escherichia coli (UPEC) strains was studied. Thirteen isolates responded to antibiotic treatment with an increase in haemagglutination titre and/or surface hydrophobicity, which correlated with a higher expression of surface proteins. Only UPEC strains with ciprofloxacin-enhanced hydrophobicity increased their adhesiveness to urinary catheters that correlated, in one analysed case, with a dramatic increase in the number of fimbriae peripherally located. The overall results indicate that sub-MICs of ciprofloxacin could increase the adhesiveness, and hence the risk of colonization by UPEC strains expressing mannose-resistant adhesins different from type P.


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