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JAC Advance Access published online on December 12, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg045
© 2002 by The British Society for Antimicrobial Chemotherapy
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© 2002 The British Society for Antimicrobial Chemotherapy

In Brief

Immunovirological outcomes in 70 HIV-1-infected patients who switched to lopinavir/ritonavir after failing at least one protease inhibitor-containing regimen: a retrospective cohort study

Marco Bongiovanni 1, Teresa Bini 1*, Federica Tordato 1, Paola Cicconi 1, Sara Melzi 1, Dolores Repetto 1, Salvatore Sollima 1, Stefano Rusconi 1, Antonella d'Arminio Monforte 1

1 Institute of Infectious and Tropical Diseases, University of Milan, Luigi Sacco Hospital, via G.B. Grassi 74, 20157 Milan, Italy

* Corresponding author. E-mail: tbini{at}mailserver.unimi.it.

Received 8 April 2002 ; revised 2 July 2002 ; accepted 20 August 2002

Abstract

The immunovirological outcome of lopinavir/ritonavir was evaluated in 70 antiretroviral-experienced HIV patients; at baseline, median CD4+ cell count was 218 cells/mm3 and median plasma viraemia 4.58 log10 copies/mL. After 12 months, we observed an increase in CD4+ cell count to 322 cells/mm3 (P = 0.0001) and a decrease in plasma viraemia to 2.35 log10 copies/mL (P = 0.0001). Four patients discontinued lopinavir/ritonavir during observation. Among metabolic parameters, only triglyceride concentrations increased during treatment (P = 0.02). Twenty-six patients had a genotypic resistance test at baseline; four had >=6 mutations known to reduce susceptibility to lopinavir/ritonavir. Undetectable plasma viraemia was obtained only in patients with <=5 mutations (61.9%).


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