JAC Advance Access published online on December 12, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg040
© 2002 by The British Society for Antimicrobial Chemotherapy
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In Brief
1 Department of Pathobiology, University
of Washington, Box 357238, School of Public Health
and Community Medicine, Seattle, WA 98195, USA
* Corresponding author. E-mail: marilynr{at}u.washington.edu.
Received 20 September 2002
; revised 4 October 2002
; accepted 9 October 2002
The presence of macrolide-lincosamide-streptogramin
B resistance genes erm(B), erm(C)
and erm(F), the macrolide resistance mef(A)
gene, and the DNA sequence of a 13 bp repeat in the promoter region
of the mtrR gene, were determined in 62 Neisseria
gonorrhoeae isolates collected between 1992 and 1999 in Seattle,
Washington, USA. Eleven isolates with erythromycin and azithromycin
MICs of
Keywords: N. gonorrhoeae, macrolide resistance,
acquired resistance
Acquired macrolide resistance genes and the 1 bp
deletion in the
mtrR promoter in Neisseria gonorrhoeae
2 Department of Medicine, University
of Washington, Box 357238, School of Public Health
and Community Medicine, Seattle, WA 98195, USA
0.06 mg/L, had no acquired
genes or deletions in the 13 bp repeat region. Among 44 isolates
with erythromycin MICs 1.0-16.0 mg/L, and azithromycin
MICs 0.06-4.0 mg/L, 16 carried the 1 bp deletion
in the mtrR promoter region alone, nine carried
one or more of the four acquired macrolide resistance genes alone,
and 14 carried both acquired macrolide resistance genes plus the
1 bp deletion in the mtrR promoter region. Three
isolates with erythromycin MICs 
8
mg/L, and azithromycin MICs of 4.0 mg/L, carried only erm genes. Five
isolates with MICs of 1-2 mg/L did not carry the 1 bp deletion,
or any of the acquired resistance genes examined. Our data suggest
that the 1 bp deletion in the mtrR promoter region
is not found in all erythromycin-resistant (MIC 1.0
mg/L) N. gonorrhoeae.
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