JAC Advance Access published online on December 12, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg037
© 2002 by The British Society for Antimicrobial Chemotherapy
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Original Paper
1 Department of Microbiology,
Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku,
Kyoto 607-8414
* Corresponding author. E-mail: arima3{at}kuhp.kyoto-u.ac.jp.
Received 3 July 2002
; revised 12 September 2002
; accepted 8 October 2002
Keywords: Antibacterial effect of
-thujaplicin
on staphylococci isolated from atopic dermatitis: relationship between
changes in the number of viable bacterial cells and clinical improvement
in an eczematous lesion of atopic dermatitis
2 Department
of Environmental Dermatology, Nagoya University School of Medicine,
1-1-20 Daikominami, Higashi-ku, Nagoya 461-0047, Japan
-Thujaplicin (hinokitiol)
is a tropolone-related compound purified from the wood of Chamaecyparis
obtusa, Sieb. et Zucc. and Thuja
plicata D. Don. All Staphylococcus aureus isolates
were inhibited by -thujaplicin with
MICs of 1.56-3.13 mg/L. However, a paradoxical zone phenomenon
occurred, with each isolate producing regrowth at higher -thujaplicin
concentrations. Other antimicrobial agents showed a wide range of
MICs. The combination of -thujaplicin
and zinc oxide inhibited the paradoxical zone phenomenon, and enhanced
killing activity against clinically isolated staphylococci. Large
numbers of viable bacterial cells, especially S. aureus cells,
were detected in the skin surface of atopic dermatitis, in comparison
with those in healthy volunteers. The number of cells increased
as the severity of the skin condition worsened. Topical application
of -thujaplicin resulted in a reduction
in the number of bacterial cells on the skin surface, and an improvement
in skin condition after treatment. The results of this study suggest
that the degree of reduction in the number of viable bacterial cells
in an eczematous lesion of atopic dermatitis is related to the degree
of improvement in skin condition.-thujaplicin, staphylococci,
MRSA, atopic dermatitis, zinc oxide
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