JAC Advance Access published online on January 6, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg032
© 2003 by The British Society for Antimicrobial Chemotherapy
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Original article
1 Public Health Laboratory,
University Hospital Wales, Cardiff, South Glamorgan CF14 4XW
* Corresponding author. E-mail: theanyen.tan{at}phls.wales.nhs.uk.
Received 25 June 2002
; revised 26 August 2002
; accepted 9 October 2002
This study set out to investigate whether there was
an association between antibiotic susceptibility reporting from
microbiology laboratories and antibiotic prescribing for urinary tract
infections in the community. Data were collected over a 3 month
period using a prospective questionnaire survey of general practitioners,
who submitted and received a mid-stream urine (MSU) result from
selected microbiology laboratories in England and Wales. In addition, prescribing
analyses and cost (PACT) data were requested from the Prescription
Prescribing Authority. The study demonstrated an association between
laboratory reporting of antibiotic susceptibilities and antibiotic
prescribing for treatment of urinary tract infections. The reporting of
susceptibilities to oral cephalosporins and nitrofurantoin from
microbiology laboratories was associated with increased prescribing
of each antibiotic. This association was demonstrated for the choice
of empirical antibiotic therapy and the choice of antibiotic prescribed
for each studied episode of urinary tract infection. PACT data demonstrated
a consistently greater use of antibiotics that were reported by
the servicing laboratory, although this was only statistically significant
for nitrofurantoin. This study demonstrates that there is an association
between antibiotic susceptibility reporting from microbiology laboratories
and antibiotic prescribing for the treatment of urinary tract infections.
Keywords: antibiotic reporting, prescribing, microbiology
laboratory
Laboratory antibiotic susceptibility reporting
and antibiotic
prescribing in general practice
2 Public Health Laboratory, Gloucester
3 Statistics Department, Communicable
Disease Surveillance Centre, London
4 NHS Executive South West, Department of Health,
Bristol, UK
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