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JAC Advance Access published online on January 6, 2003
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg026
© 2003 by The British Society for Antimicrobial Chemotherapy
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© 2003 The British Society for Antimicrobial Chemotherapy

Brief reports

Ex vivo synergy of arachidonate-enriched serum with ceftazidime and amikacin on multidrug-resistant Pseudomonas aeruginosa

Evangelos J. Giamarellos-Bourboulis 1, Diamantis Plachouras 1, Sotirios Skiathitis 2, Maria Raftogiannis 1, Amalia Dionyssiou-Asteriou 3, Ismini Dontas 2, Panayotis E. Karayannacos 2, Helen Giamarellou 1*

1 4th Department of Internal Medicine, Sismanoglio General Hospital, 1 Sismanogliou Str., 151 26 Maroussi Attikis
2 Laboratory for Experimental Surgery and Surgical Research, University of Athens, Medical School, Athens
3 Department of Biological Chemistry, University of Athens, Medical School, Athens, Greece

* Corresponding author. E-mail: giamarel{at}internet.gr.

Received 2 April 2002 ; revised 8 August 2002 ; accepted 27 September 2002

Abstract

Three multidrug-resistant strains of Pseudomonas aeruginosa were incubated ex vivo with sera sampled after a 10 min intravenous infusion of 25 mg/kg of arachidonic acid (AA) in 10 rabbits in the presence of ceftazidime and amikacin. Lipid peroxidation was assessed during bacterial growth. A statistically significant decrease in bacterial cells was found by the interaction of antimicrobials and serum sampled in the middle of infusion and 15 and 30 min after infusion of AA and was accompanied by elevated levels of malonodialdehyde. This effect of AA is probably attributed to lipid peroxidation and raises the possibility of its application in experimental infections.


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