JAC Advance Access published online on November 18, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkg006
© 2002 by The British Society for Antimicrobial Chemotherapy
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In Brief
1 Laboratory of Clinical Microbiology, L. Sacco Teaching Hospital,
University of Milan, Via GB Grassi 74,
20157 Milan, Italy
* Corresponding author. E-mail: microbio{at}mailserver.unimi.it.
Received 30 May 2002
; revised 18 July 2002
; accepted 22 September 2002
This study aimed to evaluate the bactericidal rates
of levofloxacin, gatifloxacin, penicillin, meropenem and rokitamycin
against seven isolates of Bacillus anthracis clinically
isolated between 1960 and 1970. After determination of MIC and MBC,
time-kill experiments were carried out. Antimicrobial activity
was evaluated at concentrations equal to 1 x,
2 x, 4 x and
8 x MIC after 0, 3, 6, 12 and 24 h of
incubation with the drugs. Bactericidal activity was defined as
a decrease in bacterial count of at least 3 log10. All
the isolates were susceptible to all the antibiotics, by considering
the antistaphylococcal breakpoints. Levofloxacin was bactericidal
at 1 x MIC after 24 h and at 4 x MIC after
12 h, and gatifloxacin was bactericidal at 2 x MIC
after 24 h and at 8 x MIC after 12 h. Meropenem,
rokitamycin and penicillin also showed bactericidal activity at
concentrations of 4 x and 8 x MIC, respectively, but only after
24 h incubation; after the same time, meropenem and rokitamycin
showed a more marked killing than penicillin at 2 x MIC.
Keywords: Bacillus anthracis, anthrax,
fluoroquinolones, penicillin, meropenem, rokitamycin, macrolides, in vitro susceptibility testing
Bactericidal activity of levofloxacin, gatifloxacin,
penicillin, meropenem and rokitamycin against Bacillus
anthracis clinical isolates
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