JAC Advance Access published online on November 18, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf255
© 2002 by The British Society for Antimicrobial Chemotherapy
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Original Paper
1 Centro Nacional de Microbiología,
Instituto de Salud Carlos III, Carretera Pozuelo a Majadahonda,
28220 Majadahonda, Madrid, Spain
* Corresponding author. E-mail: jcampos{at}isciii.es.
Received 22 July 2002
; revised 10 September 2002
; accepted 20 September 2002
In Europe, antimicrobial resistance of invasive pathogens
has been monitored since 1998 by the European Antimicrobial Resistance
Surveillance System (EARSS). The goal of this study is to analyse
the susceptibility data of invasive Escherichia coli collected
by 27 Spanish laboratories in 2001. Each laboratory identified strains
and tested their susceptibility using its own methods. To assess
the comparability of susceptibility test results, a quality assurance
exercise was performed. We report data from 1962 invasive isolates
of E. coli: 1959 from blood and three from cerebrospinal
fluid, corresponding to the same number of patients. Resistance
to ampicillin, co-trimoxazole, ciprofloxacin and gentamicin was
found in 58.46%, 32.91%, 17.19% and 6.39%
of isolates, respectively. Extended-spectrum
Keywords: antimicrobial resistance, invasive infections,
EARSS, Escherichia coli
Antibiotic resistance in 1962 invasive isolates
of Escherichia coli in
27 Spanish hospitals participating in the European Antimicrobial Resistance
Surveillance System (2001)
2 Servicio
de Microbiología, H. Ramón y Cajal, Madrid, Spain
-lactamase
(ESBL) production was detected in 30 strains (1.55%).
Ciprofloxacin resistance was higher in isolates from men and in-patients
than in those from women and out-patients (P < 0.001).
Resistance to ampicillin and co-trimoxazole was more widespread
in children than in adults: 70.37% versus 57.87% (P = 0.01) and 41.84% versus 32.53% (P = 0.05). Non-significant differences
in resistance to fluoroquinolones were observed between isolates
from children (11.1%) and adults (17.54%), despite
the fact that fluoroquinolones are not administered to children.
Significantly, resistance to non--lactam antibiotics
(co-trimoxazole, ciprofloxacin and gentamicin) was more prevalent
in ampicillin-resistant strains and ESBL-producing strains than
in ampicillin-susceptible strains and non-ESBL-producing
strains. Multidrug resistance was present in 13.92% of
isolates; the most prevalent phenotype was resistance to ampicillin,
co-trimoxazole and ciprofloxacin, which was detected in 59.36% of
multiresistant strains and in 8.22% of strains overall.
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