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JAC Advance Access published online on November 18, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf250
© 2002 by The British Society for Antimicrobial Chemotherapy
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© 2002 The British Society for Antimicrobial Chemotherapy

Original Paper

Additive, indifferent and antagonistic effects in combinations of epigallocatechin gallate with 12 non-{beta}-lactam antibiotics against methicillin-resistant Staphylococcus aureus

Zhi-Qing Hu 1*, Wei-Hua Zhao 1, Yoshiyuki Yoda 1, Nozomi Asano 1, Yukihiko Hara 2, Tadakatsu Shimamura 1

1 Department of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
2 Tokyo Food Techno Co., Ltd, Tokyo, Japan

* Corresponding author. E-mail: zqhu{at}med.showa-u.ac.jp.

Received 23 July 2001 ; revised 27 December 2001 ; accepted 9 September 2002

Abstract

Additive, indifferent and antagonistic effects were observed in combinations of epigallocatechin gallate (EGCg, a main constituent of tea catechins) with12 non-{beta}-lactam antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). The combinations of EGCg with the inhibitors of either protein or nucleic acid synthesis showed additive or indifferent effects. These antibiotics included tetracycline, minocycline, chloramphenicol, streptomycin, gentamicin, kanamycin, erythromycin, rifampicin and ofloxacin. In contrast, EGCg showed an antagonistic tendency against glycopeptide antibiotics (vancomycin, teicoplanin and polymyxin B). The common property of these antibiotics is the peptide backbone structure, suggesting a direct binding of EGCg with the antibiotics. The above results indicate that tea catechins may affect the activities of antibiotics both positively and negatively.


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