JAC Advance Access published online on October 22, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf246
© 2002 by The British Society for Antimicrobial Chemotherapy
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In Brief
1 Southampton Public Health
Laboratory, Southampton General Hospital, Southampton SO16 6YD
* Corresponding author. E-mail: cressida{at}doctors.org.uk.
Received 12 June 2002
; revised 13 September 2002
Linezolid, the first oxazolidinone antibacterial agent
to be developed for clinical use, was licensed in the UK in early
2001. We report the first three examples of resistant enterococci
(two isolates of Enterococcus faecium and one Enterococcus faecalis) isolated in the UK, which
were obtained from patients who had received linezolid. The linezolid
MICs for the resistant isolates were 64 mg/L. Pulsed-field gel electrophoresis
(PFGE) analysis of the linezolid-susceptible and -resistant isolates
from two of the patients, combined with sequence analysis of rRNA,
indicated that resistance developed in previously susceptible strains,
most probably via a point mutation in the 23S rRNA.
Keywords: linezolid, resistance, enterococci
Linezolid-resistant enterococci: report of the
first isolates in the
United Kingdom
2 Chelmsford Public Health
Laboratory
3 Department of
Microbiology, Hammersmith Hospital
4 Laboratory of Hospital Infection,
Central Public Health Laboratory, Colindale, London
5 Antibiotic Resistance Monitoring
and Reference Laboratory, Central Public Health Laboratory, Colindale,
London, UK
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