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JAC Advance Access published online on October 8, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf218
© 2002 by The British Society for Antimicrobial Chemotherapy
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© 2002 The British Society for Antimicrobial Chemotherapy

In Brief

In vitro activity of sitafloxacin (DU-6859a) alone, or in combination with rifampicin, against Mycobacterium ulcerans

Arvind M. Dhople 1* Kenji Namba 2

1 Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901, USA
2 Daiichi Pharmaceutical Company, Ltd, Tokyo, Japan

* Corresponding author. E-mail: adhople{at}fit.edu.

Received 7 June 2002 ; revised 9 August 2002 ; accepted 20 August 2002

Abstract

The antimicrobial effect of sitafloxacin (DU-6859a), used either singly or in combination with rifampicin, was evaluated in vitro against Mycobacterium ulcerans. Growth of M. ulcerans was measured by plate counts and the BACTEC radiometric method. The MICs and MBCs of sitafloxacin for M. ulcerans were in the range 0.125-0.5 mg/L. The values for other fluoroquinolones were two- to four-fold higher than for sitafloxacin. Combination of sitafloxacin and rifampicin exhibited synergy with five of the eight strains, whereas the combination of ofloxacin and rifampicin resulted in additive effects only. These results suggest that the combination of sitafloxacin and rifampicin has potential in the treatment of M. ulcerans infection.

Keywords: sitafloxacin, Mycobacterium ulcerans, ofloxacin, rifampicin
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