JAC Advance Access published online on November 1, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf217
© 2002 by The British Society for Antimicrobial Chemotherapy
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Original Paper
1 Telemark Biomedical Centre,
A/S Telelab, Department of Medical Microbiology, Strømdaljordet
4, PO Box 1868,
N-3703 Skien, Norway
* Corresponding author. E-mail: yngvar.tveten{at}telelab.no.
Received 2 July 2002
; revised 20 August 2002
; accepted 20 August 2002
Objective: To investigate the possibility
that the increased prevalence of fusidic acid-resistant Staphylococcus
aureus in Norway is caused by clonal spread. Methods: Fusidic acid-resistant and -susceptible
clinical isolates of S. aureus from patients with skin
infections in the Norwegian county of Telemark and fusidic acid-resistant
isolates from other parts of Scandinavia were compared. MICs of
fusidic acid for bacterial isolates and pulsed-field gel electrophoresis
(PFGE) patterns were investigated. Prevalence data for fusidic acid-resistant S. aureus for the period 1992-2001 were
obtained. Results: The prevalence of fusidic acid resistance
in S. aureus increased from 1992 to 2001. Eighty
per cent of the resistant isolates investigated shared an identical
PFGE pattern. The same pattern was found in fusidic acid-resistant
isolates from other parts of Scandinavia. Fusidic acid-resistant S. aureus was typically found in impetigo bullosa-like
skin disease in children mostly in the summer months. Conclusions: Fusidic acid resistance among S. aureus is increasing in Norway and is predominantly
caused by one clone of S. aureus. The clone may
spread further to other countries, and dissemination may be facilitated
by extensive use of topical fusidic acid.
Keywords: pulsed-field gel electrophoresis, MIC, clonal
A fusidic acid-resistant clone of Staphylococcus
aureus associated with impetigo bullosa is spreading in Norway
2 Telemark Biomedical Centre,
A/S Telelab, Department of Medical Microbiology, Strømdaljordet
4, PO Box 1868,
N-3703 Skien, Norway; Department
of Microbiology and Virology, University of Tromsø, N-9037
Tromsø, Norway
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