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JAC Advance Access published online on September 20, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf200
© 2002 by The British Society for Antimicrobial Chemotherapy
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© 2002 The British Society for Antimicrobial Chemotherapy

In Brief

Evidence for the efficacy of artesunate in asymptomatic Plasmodium malariae infections

Steffen Borrmann 1*, Nicole Szlezák 2, Ronald K. Binder 3, Michel A. Missinou 1, Bertrand Lell 1, Peter G. Kremsner 1

1 Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, B. P. 118, Gabon; Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Wilhelmstrasse 27, D-72074 Tübingen, Germany
2 Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, B. P. 118, Gabon; John F. Kennedy School of Government, Harvard University, Cambridge, MA 02138, USA
3 Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, B. P. 118, Gabon

* Corresponding author. E-mail: steffen.borrmann{at}uni-tuebingen.de.

Received 10 January 2002 ; revised 16 May 2002 ; accepted 12 August 2002

Abstract

This study evaluated the efficacy and safety of a 3-day course of artesunate (4 mg/kg/day) for asymptomatic Plasmodium malariae infections. The parasitological cure rates on days 7 and 56 in the group treated with artesunate were 100% and 83%, respectively, compared with no cure in the placebo group (P < 0.0001).

Keywords: Plasmodium malariae, artesunate, chemotherapy, malaria, Gabon
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