JAC Advance Access published online on October 22, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf193
© 2002 by The British Society for Antimicrobial Chemotherapy
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Original Paper
1 Service de Bactériologie,
Hôpital Saint Antoine,UFR Saint-Antoine, 184 rue du Faubourg
Saint-Antoine, 75012 Paris
* Corresponding author. E-mail: dominique.decre{at}sat.ap-hop-paris.fr.
Received 13 November 2001
; revised 1 May 2002
; accepted 2 August 2002
We isolated five clinical strains (three Proteus
mirabilis and two Klebsiella pneumoniae) with
ß-lactam resistance phenotypes
consistent with production of an AmpC-type ß-lactamase.
The predicted amino acid sequences of the enzymes were typical
of class C ß-lactamases. The enzymes
were identified as CMY-2, CMY-4 and a new CMY-variant ß-lactamase,
CMY-12. The AmpC ß-lactamases from the
two K. pneumoniae isolates were found to be encoded
on self-transferable plasmids. The genes encoding the AmpC-type ß-lactamase produced by the three P. mirabilis isolates were chromosomal. Four of
the five clinical isolates were from patients transferred from Greece,
Algeria and Egypt; one of the K. pneumoniae strains
was recovered from a French patient. PFGE analysis and rep-PCR fingerprinting
showed that the two P. mirabilis isolates from
Greek patients were closely related.
Characterization of CMY-type ß-lactamases
in clinical strains of
Proteus mirabilis and Klebsiella pneumoniae isolated
in
four hospitals in the Paris area
2 Service
de Bactériologie, Hôpital Tenon, UFR Saint-Antoine,
Paris
3 Service de Bactériologie
Hôpital Lariboisière
4 Service de Bactériologie, CHU Cochin,
AP-HP, Paris, France
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