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JAC Advance Access published online on November 1, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf186
© 2002 by The British Society for Antimicrobial Chemotherapy
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© 2002 The British Society for Antimicrobial Chemotherapy

In Brief

Mechanisms of {beta}-lactam resistance in Pseudomonas aeruginosa: prevalence of OprM-overproducing strains in a French multicentre study (1997)

J. D. Cavallo 1*, P. Plesiat 2, G. Couetdic 2, F. Leblanc 3, R. Fabre 1

1 Hôpital d'Instruction des Armées Bégin, 69 Avenue de Paris, 94163 St Mandé, France
2 Faculté de Médecine de Besançon, Besançon, France
3 Laboratoire Glaxo-Wellcome, 100 route de Versailles, 78163 Marly le Roi, France

* Corresponding author. E-mail: hia-begin-biologie{at}worldonline.fr.

Received 3 April 2002 ; revised 12 July 2002 ; accepted 23 July 2002

Abstract

One hundred and forty-three non-repetitive strains of Pseudomonas aeruginosa were collected in 13 French hospitals in 1997. A decreased susceptibility or resistance to ticarcillin (MIC > 16 mg/L) was found in 61 isolates (43%) and this was attributed to three major mechanisms: (i) overexpression of OprM and hence related efflux components such as MexAB or MexXY (42.6%), (ii) production of acquired {beta}-lactamase (29.5%) and (iii) overexpression of chromosomally encoded AmpC cephalosporinase (21.3%). Four of seven ‘intrinsically' resistant strains (11.5%) with normal amounts of OprM were shown to produce low levels of AmpC, whereas in three isolates no resistance mechanism to {beta}-lactams could be identified. Overproduction of OprM thus appears as an important mechanism of ticarcillin resistance in French isolates of P. aeruginosa.


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