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JAC Advance Access published online on September 6, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf179
© 2002 by The British Society for Antimicrobial Chemotherapy
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© 2002 The British Society for Antimicrobial Chemotherapy

In Brief

Brain tissue penetration of ciprofloxacin following a single intravenous dose

Marc Leone 1*, Emmanuelle Sampol-Manos 2, Dominique Santelli 1, Stéphanie Grabowski 2, Bernard Alliez 3, Alain Durand 2, Bruno Lacarelle 2, Claude Martin 1

1 Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles School of Medicine, Marseilles
2 Department of Pharmacokinetics, Timone Hospital, France
3 Department of Neurosurgery, Nord Hospital, Marseilles School of Medicine, Marseilles

* Corresponding author. E-mail: marc.leone{at}ap-hm.fr.

Received 18 February 2002 ; revised 18 June 2002 ; accepted 15 July 2002

Abstract

Ciprofloxacin distribution was assessed in cerebral tissues in 14 patients undergoing craniotomy. The study objective was to determine the brain tissue/serum concentration ratio of ciprofloxacin. Patients received a single intravenous (iv) 200 mg dose of ciprofloxacin. Mean (± S.D.) tissue/serum concentration ratios were (mg/kg): parietal fat during opening 1.40 ± 1.05, during closure 1.34 ± 1.17, in the dura mater 2.26 ± 1.36, in skull bone during opening 0.44 ± 0.29, during closure 0.97 ± 1.57 and in brain tissue 0.88 ± 0.99. Mean (± S.D.) concentrations of ciprofloxacin in brain tissue were 0.87 ± 0.08 mg/kg, suggesting that a dose >200 mg iv ciprofloxacin is required to ensure therapeutic concentrations in brain tissue.


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