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JAC Advance Access published online on September 20, 2002
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkf178
© 2002 by The British Society for Antimicrobial Chemotherapy
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© 2002 The British Society for Antimicrobial Chemotherapy

Original Paper

Pharmacokinetics and ocular penetration of grepafloxacin in albino and pigmented rabbits

S. Perez 1, C. Solans 2, M. A. Bregante 3*, I. Pinilla 1, M. A. García 2, F. Honrubia 1

1 Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Isabel La Catolica 1-3, E-50009
2 Department of Analytical Chemistry, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Miguel Servet 177, E-50013, Spain
3 Department of Pharmacology and Physiology, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Miguel Servet 177, E-50013, Spain

* Corresponding author. E-mail: Bregante{at}posta.unizar.es.

Received 23 November 2001 ; revised 25 March 2002 ; accepted 15 July 2002

Abstract

The pharmacokinetics of grepafloxacin were determined in albino and pigmented rabbits following a single 10 mg/kg intravenous administration. The penetration of grepafloxacin into various ocular tissues was also determined after continuous intravenous infusion in both types of animal. Grepafloxacin showed a bicompartmental model of distribution in both pigmented and albino rabbits with significant differences in the pharmacokinetics between the two types of animal. After continuous intravenous infusion, significantly greater penetration of grepafloxacin was found in the iris, cornea and chorioretina of pigmented rabbits compared with albino rabbits.


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