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JAC Advance Access originally published online on June 30, 2009
Journal of Antimicrobial Chemotherapy 2009 64(3):654-657; doi:10.1093/jac/dkp234
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Only for substrate antibiotics are a functional AcrAB–TolC efflux pump and RamA required to select multidrug-resistant Salmonella Typhimurium

Vito Ricci and Laura J. V. Piddock*

Antimicrobial Agents Research Group, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK

* Corresponding author. Tel: +44-121-414-6966; Fax: +44-121-414-6819; E-mail: l.j.v.piddock@bham.ac.uk

Keywords: substrate specificity , ramA , AcrB , TolC

The first 10% of the full text of this article appears below.

Sir,

Previous work from our laboratory showed that a functional AcrAB–TolC system in Salmonella enterica serovar Typhimurium is required for the selection of ciprofloxacin-resistant mutants.1 Baucheron et al.2,3 also showed that Salmonella genomic island 1-encoded chloramphenicol and tetracycline resistance, as well as chromosomally encoded fluoroquinolone resistance, are also dependent upon a functional AcrAB–TolC system.

In multidrug-resistant (MDR) S. enterica, Klebsiella pneumoniae and Enterobacter aerogenes, ramA is typically overexpressed whereas other regulators, such as marA, soxS or rob that can also be involved in the . . . [Full Text of this Article]


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