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JAC Advance Access originally published online on May 9, 2009
Journal of Antimicrobial Chemotherapy 2009 64(1):206-207; doi:10.1093/jac/dkp167
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

A T2504A mutation in the 23S rRNA gene responsible for high-level resistance to linezolid of Staphylococcus epidermidis

Apostolos Liakopoulos1,2,3, Charalambos Neocleous1,2, Dimitra Klapsa1,2, Maria Kanellopoulou4, Iris Spiliopoulou5, Kostas D. Mathiopoulos3, Evangelos Papafrangas4 and Efi Petinaki1,2,*

1 Department of Microbiology, Medical School, University of Thessalia, Larissa, Greece 2 Department of Molecular Microbiology, Institute of BioMedical Research and Technology, Larissa, Greece 3 Department of Biochemistry and Biotechnology, University of Thessalia, Larissa, Greece 4 Department of Microbiology, ‘Sismanoglion’ General Hospital of Athens, Athens, Greece 5 Department of Microbiology, School of Medicine, University of Patras, Patras, Greece

* Corresponding author. Department of Microbiology, Medical School, University of Thessalia, Mezourlo, Larissa, Greece. Tel: +30-2410-682503; Fax: +30-2410-682517; E-mail: petinaki@med.uth.gr

Keywords: S. epidermidis , staphylococci , oxazolidinones

The first 10% of the full text of this article appears below.

Sir,

Linezolid is an important antimicrobial agent for the treatment of infections caused by Gram-positive organisms, including methicillin-resistant staphylococci. The mechanism of action is thought to involve the inhibition of protein synthesis through binding to the domain V region of 23S rRNA. Until now, the G2576T and T2500A mutations in the domain V region of the 23S rRNA gene (Escherichia coli 23S rRNA gene numbering) were found to be associated with the expression of linezolid resistance among clinical staphylococcal isolates, while other mutations, such as G2444T, . . . [Full Text of this Article]


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