Skip Navigation


JAC Advance Access originally published online on March 24, 2009
Journal of Antimicrobial Chemotherapy 2009 63(6):1152-1155; doi:10.1093/jac/dkp095
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
63/6/1152    most recent
dkp095v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Azor, M.
Right arrow Articles by Guarro, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Azor, M.
Right arrow Articles by Guarro, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

High genetic diversity and poor in vitro response to antifungals of clinical strains of Fusarium oxysporum

Mónica Azor, Josep Cano, Josepa Gené and Josep Guarro*

Mycology Unit, Medical School, IISPV, Universitat Rovira i Virgili, Reus, Spain

Received 7 January 2009; returned 10 February 2009; revised 20 February 2009; accepted 24 February 2009

* Corresponding author. Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain. Tel: +34-977-759359; Fax: +34-977-759322; E-mail: josep.guarro{at}urv.cat

Objectives: The aim of this study was to determine the genetic variability of clinical isolates morphologically identified as Fusarium oxysporum and to assess if there are differences in antifungal susceptibility among the possible genetic clades obtained.

Methods: Twenty-eight isolates were molecularly characterized by sequence analysis of the elongation factor 1{alpha} gene. The antifungal susceptibilities of these isolates to 11 antifungal drugs were tested using a microdilution method.

Results and conclusions: We obtained four different phylogenetic clades in the molecular study. Although all the antifungals tested showed poor activity against all the genetic clades, terbinafine showed the best results.

Keywords: Fusarium , molecular identification , elongation factor 1{alpha} gene , antifungal susceptibility


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.