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JAC Advance Access originally published online on October 7, 2008
Journal of Antimicrobial Chemotherapy 2008 62(6):1319-1322; doi:10.1093/jac/dkn418
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Effect of fluoroquinolones on body temperature of mice

Shuichi Miyazaki1,*, Fumio Ishikawa2, Saburo Matsuo3 and Keizo Yamaguchi1

1 Department of Microbiology and Infectious Disease, Toho University Faculty of Medicine School of Medicine, Tokyo, Japan 2 Immunology, Toho University Faculty of Medicine School of Medicine, Tokyo, Japan 3 Laboratory of Toxicology, Course of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Japan

Received 17 July 2008; returned 8 August 2008; revised 10 September 2008; accepted 11 September 2008

* Corresponding author. Tel: +81-3-3762-4151, ext. 2395; Fax: +81-3-5493-5415; E-mail: shuichi{at}med.toho-u.ac.jp

Objectives: The purpose of this study was to assess the effect of fluoroquinolones on rectal temperature of infected and non-infected mice.

Methods: The effect of fluoroquinolone administration on rectal temperature was investigated in a mouse model with and without infection.

Results: Hypothermia was induced by administration of gatifloxacin at doses of 1 and 10 mg/kg in non-infected mice, but not by cefditoren pivoxil. In addition, the rectal temperature was decreased in infected mice administered fluoroquinolones or cephems, a greater decrease being noted in animals receiving the former agents.

Conclusions: This study shows that fluoroquinolones decrease the rectal temperature of mice regardless of infections.

Keywords: hypothermic effect , mouse model , CAP , community-acquired pneumonia


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