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JAC Advance Access originally published online on October 18, 2008
Journal of Antimicrobial Chemotherapy 2008 62(6):1169-1173; doi:10.1093/jac/dkn424
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

Development of antiviral agents for enteroviruses

Tzu-Chun Chen1,2,3, Kuo-Feng Weng1,2, Shih-Cheng Chang1,2, Jing-Yi Lin1,2, Peng-Nien Huang1,2 and Shin-Ru Shih1,2,4,5,*

1 Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan 2 Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan 3 Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan 4 Clinical Virology Laboratory, Chang Gung Memorial Hospital, Taoyuan, Taiwan 5 Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Chunan, Taiwan

* Correspondence address. Department of Medical Biotechnology and Laboratory Science, Chang Gung University, 259 Wen-Hua 1st Road, Kwei-Shan, Taoyuan 333, Taiwan, Republic of China. Tel: +886-3-2118800, ext. 5497; Fax: +886-3-2118174; E-mail: srshih{at}mail.cgu.edu.tw

Enteroviruses (EVs) are common human pathogens that are associated with numerous disease symptoms in many organ systems of the body. Although EV infections commonly cause mild or non-symptomatic illness, some of them are associated with severe diseases such as CNS complications. The current absence of effective vaccines for most viral infection and no available antiviral drugs for the treatment of EVs highlight the urgency and significance of developing antiviral agents. Several key steps in the viral life cycle are potential targets for blocking viral replication. This article reviews recent studies of antiviral developments for EVs based on various molecular targets that interrupt viral attachment, viral translation, polyprotein processing and RNA replication.

Keywords: capsid proteins , viral proteases , viral RNA replication , 5' untranslated region


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 Antimicrob. Agents Chemother.Home page
T.-C. Chen, H.-Y. Chang, P.-F. Lin, J.-H. Chern, J. T.-A. Hsu, C.-Y. Chang, and S.-R. Shih
Novel Antiviral Agent DTriP-22 Targets RNA-Dependent RNA Polymerase of Enterovirus 71
Antimicrob. Agents Chemother., July 1, 2009; 53(7): 2740 - 2747.
[Abstract] [Full Text] [PDF]


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