Skip Navigation


JAC Advance Access originally published online on July 25, 2008
Journal of Antimicrobial Chemotherapy 2008 62(5):855-859; doi:10.1093/jac/dkn305
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
62/5/855    most recent
dkn305v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hilton, R.
Right arrow Articles by Tong, C. Y. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hilton, R.
Right arrow Articles by Tong, C. Y. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading articles

Antiviral therapy for polyomavirus-associated nephropathy after renal transplantation

Rachel Hilton1 and C. Y. William Tong2,3,*

1 Renal, Transplant and Urology Services, Guy's and St Thomas' NHS Foundation Trust, London, UK 2 Infection and Immunology Services, Guy's and St Thomas' NHS Foundation Trust, London, UK 3 Department of Infectious Diseases, King's College London School of Medicine, London, UK

* Correspondence address. Infection and Immunology, 5th Floor North Wing, St Thomas' Hospital, London SE1 7EH, UK. Tel: +44-20-71883147; Fax: +44-20-71883146; E-mail: william.tong{at}gstt.nhs.uk

Polyomavirus-associated nephropathy (PVAN) has recently emerged as an important cause of allograft failure following renal transplantation. The BK virus is the most important polyomavirus associated with this condition. The mainstay of therapy for PVAN is a prompt immunosuppressive dose reduction in conjunction with careful monitoring for BK viraemia. A number of antiviral agents have been tried to help to reduce BK viral replication. So far, there has been only a single randomized controlled study on the use of one of these agents. Pooled data from various small case series did not show significant differences in outcome. Prospective randomized studies with a standardized protocol are urgently required.

Keywords: BK virus , renal transplantation , cidofovir , leflunomide , fluoroquinolones , intravenous immunoglobulin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
D. R. J. Kuypers, B. Bammens, K. Claes, P. Evenepoel, E. Lerut, and Y. Vanrenterghem
A single-centre study of adjuvant cidofovir therapy for BK virus interstitial nephritis (BKVIN) in renal allograft recipients
J. Antimicrob. Chemother., February 1, 2009; 63(2): 417 - 419.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.