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JAC Advance Access originally published online on June 18, 2008
Journal of Antimicrobial Chemotherapy 2008 62(4):843-844; doi:10.1093/jac/dkn264
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Description of an unusual class 2 integron in Shigella sonnei isolates in Senegal (sub-Saharan Africa)

Amy Gassama Sow1,*, Mamadou Hadi Diallo1, Martine Gatet2,3, François Denis2,3,4, Awa Aïdara-Kane1 and Marie-Cécile Ploy2,3,4

1 Laboratoire de Bactériologie Expérimentale, Institut Pasteur, 220 Dakar, Sénégal 2 Université de Limoges, Faculté de Médecine, EA3175, Limoges 87000, France 3 INSERM, Equipe Avenir, Limoges 87000, France 4 Laboratoire de Bactériologie-Virologie-Hygiène, CHU Dupuytren, Limoges 87000, France

* Corresponding author. Tel: +221-33-839-92-35; Fax: +221-33-839-92-36; E-mail: gassama@pasteur.sn

Keywords: gene cassettes , IS911 , sat1 , S. sonnei

The first 10% of the full text of this article appears below.

Sir,

Integrons are genetic elements that acquire gene cassettes by integrase-catalysed site-specific recombination.1 Integrons contain various combinations of gene cassettes encoding antibiotic resistance determinants and are widespread among Gram-negative bacteria. Five classes of integrons have been described to date, based on the integrase coding sequence. Classes 1 and 2 are the most frequent. Class 2 was found in transposon Tn7 and its derivatives (Tn1825, Tn1826 and Tn4132), and its 3' segment contains five tns genes involved in transposon movements. The intI2 integrase gene of class 2 . . . [Full Text of this Article]


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