JAC Advance Access originally published online on May 30, 2008
Journal of Antimicrobial Chemotherapy 2008 62(3):575-578; doi:10.1093/jac/dkn212
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Original research |
Single- and multiple-dose pharmacokinetics of intravenous moxifloxacin in patients with severe hepatic impairment
1 Department of Internal Medicine, BG Clinic Bergmannstrost, Halle/Saale, Germany 2 Institute of Clinical Pharmacology, University Rostock, Rostock, Germany 3 Department of Pulmonary Medicine, Medical School Hannover, Hannover, Germany
Received 19 November 2007; returned 19 February 2008; revised 18 March 2008; accepted 28 April 2008
* Corresponding author. Tel: +49-345-132-6278; Fax: +49-345-132-6279; E-mail: juergen.barth{at}bergmannstrost.com
Objectives: The aim of this study was to investigate the single- and multiple-dose pharmacokinetics (PK) of moxifloxacin and its penetration into ascitic fluid in patients with severe liver insufficiency (Child–Pugh class C).
Patients and methods: In a single-centre, prospective, open-label study, nine adult cirrhosis patients were treated with 400 mg moxifloxacin infusion once a day. On days 1 and 3, drug concentrations in serum and ascites were determined before and at different time points up to 24 h after medication with a validated HPLC method.
Results: On day 1, serum concentrations of moxifloxacin decreased from a median of 3.7 mg/L at 1 h to 0.6 mg/L at 24 h. On day 3, serum peak and trough levels were only moderately increased in comparison with day 1, with moxifloxacin concentrations of 3.9 mg/L after 1 h and 0.6 mg/L 24 h after the third infusion. The AUC values were also slightly, but not statistically significantly, increased on day 3. Calculations of t1/2, mean residence time, CLtot and Vss revealed no significant differences between days 1 and 3. Median concentrations of moxifloxacin in ascitic fluid were 1.4 mg/L (3 h after infusion) and 1.3 mg/L (6 h) on day 1 and 2.1 mg/L (3 h) and 1.9 mg/L (6 h) on day 3. Median ascites/serum ratios did not vary between days 1 and 3.
Conclusions: PK parameters of moxifloxacin in patients with advanced liver cirrhosis differed only marginally from those from healthy control groups given in the literature. After multiple dosing, no drug accumulation was seen. Therefore, we conclude that a dose adjustment is not necessary in this patient group. Ascitic fluid reached bactericidal levels for common bacteria found in spontaneous bacterial peritonitis.
Keywords: fluoroquinolones , chronic liver insufficiency , Child C , ascites