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JAC Advance Access originally published online on May 7, 2008
Journal of Antimicrobial Chemotherapy 2008 62(2):360-363; doi:10.1093/jac/dkn196
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Ten years of antimicrobial susceptibility testing of Salmonella from Danish pig farms

Hanne-Dorthe Emborg*, Dorte Lau Baggesen and Frank Møller Aarestrup

National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark

Received 31 January 2008; returned 4 March 2008; revised 9 April 2008; accepted 9 April 2008

* Corresponding author. Tel: +45-72-34-70-68; Fax: +45-72-34-70-01; E-mail: hde{at}food.dtu.dk

Objectives: This study analysed the trends in antimicrobial resistance in Salmonella serovars and phage types from pigs in Denmark from 1997 to 2006.

Methods: Salmonella isolates collected through the Salmonella surveillance programme in pigs were serotyped and phage-typed, and susceptibilities to the following antimicrobials were determined: ampicillin, chloramphenicol, gentamicin, nalidixic acid, colistin, streptomycin, sulphonamide, tetracycline and trimethoprim.

Results: No significant development of resistance occurred within the most important serovars, except Salmonella Typhimurium. A major decrease in Salmonella Typhimurium DT12 occurred from 46.5% in 1998 to 16.8% in 2006 while DT120, DT170 and DT104 increased. Throughout the study period, 80.9% of the DT12 isolates remained susceptible to the antimicrobials tested despite an increase in antimicrobial consumption in pigs during the period. In DT120, DT170 and DT104, only 20.1%, 33.1% and 23.0%, respectively, remained fully susceptible.

Conclusions: The results support that the use of antimicrobial agents might select for multiple resistant clones and that this might be the driver of changes in antimicrobial resistance within a serovar, rather than an emergence of resistance within clones. The results of this study also support that susceptible serovars only slowly become resistant to the antimicrobials tested.

Keywords: serovars , phage types , resistance profiles , trend analyses


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