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Journal of Antimicrobial Chemotherapy 2008 61(Supplement 1):i3-i6; doi:10.1093/jac/dkm424
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Articles

Early diagnosis of fungal infection in immunocompromised patients

Rosemary A. Barnes*

Department of Medical Microbiology, College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK


* Tel: +44-29-20742166; Fax: +44-29-20742161; E-mail: barnesra{at}cardiff.ac.uk

Techniques for the diagnosis of invasive fungal infection, including antigen testing, nucleic acid detection and radiological imaging, have improved greatly in recent years. They have the potential to impact on patient management through replacing empirical antifungal strategies with targeted and pre-emptive therapy. Factors that influence performance of these diagnostic tests include underlying disease, the prevalence of fungal infection in particular populations and prophylactic antifungal drug strategies. Understanding these factors is necessary for rational use of antifungal agents and optimal management and prevention of fungal infection in immunosuppressed patients.

Keywords: Candida spp. , Aspergillus spp. , antigen detection , PCR


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