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JAC Advance Access originally published online on March 18, 2008
Journal of Antimicrobial Chemotherapy 2008 61(6):1389-1390; doi:10.1093/jac/dkn116
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Evidence for chromosomal and plasmid location of CMY-2 cephalosporinase gene in Salmonella serotype Typhimurium

A. Zioga1, J. M. Whichard2, K. J. Joyce2, E. Tzelepi1, L. S. Tzouvelekis3 and V. Miriagou1,*

1 Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece 2 Division of Foodborne, Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 3 Department of Microbiology, Medical School, University of Athens, Greece

* Corresponding author. Tel: +30-210-6478810; Fax: +30-210-6425038; E-mail: miriagou@pasteur.gr

Keywords: β-lactamase , cephalosporin , resistance

The first 10% of the full text of this article appears below.

Sir,

Resistance to extended-spectrum cephalosporins has emerged among non-typhoid salmonellae (NTS) worldwide due to acquisition of plasmid-mediated β-lactamases including CMY-2.1 The isolation frequency of CMY-2-producing NTS in the USA has gradually increased since 1996 reflecting the widespread transmission of CMY-2-positive NTS among food animal reservoirs. The blaCMY-2 gene has been disseminated by plasmids to various Salmonella serotypes including Typhimurium.2–4 We report here on a human isolate of Salmonella serotype Typhimurium harbouring a CMY-2-encoding plasmid as well as a chromosomally located copy of blaCMY-2.

Salmonella serovar Typhimurium AM19083 was submitted to the National Antimicrobial Resistance Monitoring System in 2003 from Massachusetts. Antimicrobial . . . [Full Text of this Article]


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