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JAC Advance Access originally published online on January 24, 2008
Journal of Antimicrobial Chemotherapy 2008 61(3):754-755; doi:10.1093/jac/dkn003
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Thermostable nuclease: a study of clinical impact

D. A. Enoch*, F. J. Cooke, S. Guha and N. M. Brown

Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge CB2 2QW, UK

* Corresponding author. Tel: +01223-257035; Fax: +01223-242775; E-mail: davidaenoch@hotmail.com

Keywords: bacteraemia , Staphylococcus aureus , rapid diagnosis

The first 10% of the full text of this article appears below.

Sir,

Bacteraemia due to Staphylococcus aureus is associated with a high morbidity and mortality. Early detection and treatment is critical for successful management. Unfortunately, coagulase-negative staphylococci (CoNS) are the most frequent isolates grown from blood cultures, many of which are considered skin contaminants. A test that rapidly and accurately discriminates the two would potentially allow earlier treatment of S. aureus, while reducing unnecessary antimicrobial use. Thermostable nuclease (TSN) is . . . [Full Text of this Article]


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