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JAC Advance Access originally published online on January 25, 2008
Journal of Antimicrobial Chemotherapy 2008 61(3):746-747; doi:10.1093/jac/dkm526
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

16S ribosomal RNA methylase RmtD produced by Klebsiella pneumoniae in Brazil

Kunikazu Yamane1,2, Flávia Rossi3, Maria Goreth M. A. Barberino4, Jennifer M. Adams-Haduch2, Yohei Doi2,* and David L. Paterson2,5

1 Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan 2 Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, USA 3 Division of Pathology, Hospital das Clínicas, LIM03, University of São Paulo, São Paulo, Brazil 4 Hospital Aliança, Salvador, Brazil 5 University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia

* Corresponding author. Tel: +1-412-648-6401; Fax: +1-412-648-6399; E-mail: doiy@dom.pitt.edu

Keywords: ribosomal resistance , aminoglycosides , Enterobacteriaceae

The first 10% of the full text of this article appears below.

Sir,

Aminoglycosides are bactericidal agents that are used in the treatment of life-threatening infections caused by Gram-negative pathogens. They exert their antibacterial property by blocking the peptide bond-forming translocation process through binding to the aminoacyl site (A-site) of the 16S ribosomal RNA (rRNA) that constitutes the bacterial 30S ribosome.1

The most common mechanism of resistance to aminoglycosides by Gram-negative pathogens is the production of aminoglycoside modification enzymes such as acetyltransferases, adenylyltransferases and phosphotransferases. Resistance to aminoglycosides due to production of 16S rRNA methylases has been reported for Gram-negative bacteria . . . [Full Text of this Article]


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