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JAC Advance Access originally published online on January 29, 2008
Journal of Antimicrobial Chemotherapy 2008 61(3):670-673; doi:10.1093/jac/dkn001
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Moxifloxacin versus ampicillin + gentamicin in the therapy of experimental Listeria monocytogenes meningitis

Oguz Resat Sipahi1,*, Tuncer Turhan2, Husnu Pullukcu1, Sebnem Calik1, Meltem Tasbakan1, Hilal Sipahi3, Bilgin Arda1, Tansu Yamazhan1 and Sercan Ulusoy1

1 Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Izmir, Turkey 2 Department of Neurosurgery, Faculty of Medicine, Ege University, Izmir, Turkey 3 Department of Public Health, Faculty of Medicine, Ege University, Izmir, Turkey

Received 22 July 2007; returned 24 August 2007; revised 25 December 2007; accepted 28 December 2007

* Corresponding author. Tel: +90-232-390-45-10; Fax: +90-232-342-08-71; E-mail: oguz.resat.sipahi{at}ege.edu.tr

Objectives: This study aimed to compare the antibacterial activity of moxifloxacin and ampicillin + gentamicin in the treatment of Listeria monocytogenes meningitis in a rabbit meningitis model.

Methods: Meningitis was induced by direct inoculation of a clinical strain isolated from an immunocompromised patient (107cfu/mL) into the cisterna magna of New Zealand rabbits. After 16 h of incubation, rabbits were separated into four groups: moxifloxacin (M), ampicillin + gentamicin (A), ampicillin + gentamicin 2 (A2) and control (C). Group M received 20 mg/kg moxifloxacin at the end of the incubation time and 5 h later by intravenous (iv) route. Group A received ampicillin (30 mg/kg/h) and gentamicin (2.5 mg/kg/h) by iv route with continuous infusion for 8 h in 36 mL of 0.9% NaCl, group A2 received the same dosage of gentamicin and ampicillin in two different 36 mL 0.9% NaCl solutions and group C did not receive any treatment. Cerebrospinal fluid (CSF) samples (0.1–0.25 mL) were obtained 16 and 24 h after induction of meningitis.

Results: At the end of the 16 h of incubation, CSF bacterial counts were similar in all groups (P > 0.05). At the final stage of the study (24 h after induction of meningitis), bacterial counts in all treatment groups were significantly lower than the control group (P < 0.05). When the three treatment groups were compared, bacterial counts were found to be similar (P > 0.05).

Conclusions: These data suggest that antibacterial activity of moxifloxacin is similar to ampicillin + gentamicin in the treatment of experimental L. monocytogenes meningitis of rabbits.

Keywords: listeriosis , quinolones , rabbits , central nervous system infections


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