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JAC Advance Access originally published online on December 21, 2007
Journal of Antimicrobial Chemotherapy 2008 61(2):458-460; doi:10.1093/jac/dkm483
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Prevalence and characterization of macrolide-lincomycin-streptogramin B-resistant Staphylococcus aureus in Korean hospitals

Young-Hee Jung1, Kwang Wook Kim1, Kyeong Min Lee1, Jae Il Yoo1, Gyung Tae Chung1, Bong Soo Kim2, Hyo-Sun Kwak3 and Yeong Seon Lee1,*

1 Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Republic of Korea 2 Division of Biodefence Research, Center for Infectious Disease Research, National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Republic of Korea 3 Food Microbiology Team, Center for Food Safety Evaluation, Korea Food and Drug Administration, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-704, Republic of Korea

* Corresponding author. Tel: +82-2-380-1478; Fax: +82-2-380-1550; E-mail: yslee07@nih.go.kr

Keywords: macrolide resistance genes , double disc diffusion , non-tertiary hospitals

The first 10% of the full text of this article appears below.

Sir,

Resistance to macrolide, lincosamide and streptogramin B (MLSB) antibiotics in Staphylococcus spp. is mediated by a methylase encoded by erythromycin ribosome methylation (erm) genes or ATP transporter efflux pumps encoded by the msr or mef genes. The methylation of the 50S ribosomal subunit by erm gene products causes constitutive or inducible resistance to MLSB antibiotics. Constitutively resistant MLSB (MLSBc) strains and inducibly resistant MLSB (MLSBi) strains express erm genes, erm(A) or/and erm(C). In this study, we investigated and characterized the constitutive . . . [Full Text of this Article]


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