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JAC Advance Access originally published online on November 20, 2007
Journal of Antimicrobial Chemotherapy 2008 61(2):455-457; doi:10.1093/jac/dkm455
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Intercontinental travels of patients and dissemination of plasmid-mediated carbapenemase KPC-3 associated with OXA-9 and TEM-1

Laurent Dortet1, Irina Radu1, Valérie Gautier2, François Blot3, Elisabeth Chachaty1 and Guillaume Arlet2,4,*

1 Service de Microbiologie Médicale, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France 2 Université Pierre et Marie Curie-Paris 6, EA 2392, Laboratoire de Bactériologie, Paris, France 3 Service de Réanimation, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France 4 Assistance Publique—Hôpitaux de Paris, Hôpital Tenon, Service de Bactériologie, Paris, France

* Correspondence address. Service de Bactériologie, Hôpital Tenon, 4 rue de la Chine, 75970 Paris Cedex 20, France. Tel: +33-1-56-01-70-18; E-mail: guillaume.arlet@tnn.aphp.fr

Keywords: β-lactamases , carbapenems , Enterobacter cloacae

The first 10% of the full text of this article appears below.

Sir,

Among β-lactam antibiotics, carbapenems are those that have the highest stability towards the hydrolytic activity of most of the innate natural and acquired extended-spectrum β-lactamases prevalent within bacterial species involved in clinical practice. However, emergence of acquired carbapenem-hydrolysing β-lactamases, i.e. carbapenemases, which were first recognized in the early 1990s in some isolates of opportunistic Gram-negative bacilli, has been increasingly reported from various parts of the world during the last decade.1 Carbapenem-hydrolysing β-lactamases can be metallo-β-lactamases, expanded-spectrum oxacillinases or Ambler class A enzymes.1,2 KPC β-lactamases are class A . . . [Full Text of this Article]


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