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JAC Advance Access originally published online on November 2, 2007
Journal of Antimicrobial Chemotherapy 2008 61(1):221-222; doi:10.1093/jac/dkm420
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Multidrug-resistant Pseudomonas aeruginosa isolate co-expressing extended-spectrum β-lactamase PER-1 and metallo-β-lactamase VIM-2 from Turkey

Yusuf Yakupogullari1, Laurent Poirel2, Sandrine Bernabeu2, Ahmet Kizirgil3 and Patrice Nordmann4,*

1 Malatya State Hospital, Clinic Microbiology Laboratory, 44000 Malatya, Turkey 2 UPRES EA3539, South-Paris Medical School, 94275 Le K-Bicêtre, France 3 Firat University Medical Center, Clinic Microbiology Laboratory, 23000 Elazig, Turkey 4 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris and UPRES EA3539, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 Le K-Bicêtre, France

* Corresponding author. Tel: +33-1-45-21-36-32; Fax: +33-1-45-21-63-40; E-mail: nordmann.patrice@bct.aphp.fr

Keywords: P. aeruginosa , ESBLs , MBLs

The first 10% of the full text of this article appears below.

Sir,

The emergence of acquired metallo-β-lactamases (MBLs) in Gram-negative bacteria, especially in Pseudomonas spp., gives rise to significant therapeutic challenges for treating nosocomial infections due to multidrug-resistant pathogens.1 The first reports of transferable MBLs reported IMP types at the end of the 1980s in Japan. The most common MBL identified worldwide is now VIM-2,1,2 but only VIM-5 and IMP-1 MBLs have been identified in Turkey to date.1,3 Although clavulanic acid-inhibited extended-spectrum β-lactamases (ESBLs) are rarely reported from Pseudomonas aeruginosa, ESBL . . . [Full Text of this Article]


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